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Tricalm (Trihexyphenidyl Hydrochloride) Tablet
- Used as an adjunct therapy in all forms of Parkinsonism (idiopathic, postencephalitic, arteriosclerotic).
- Often combined with levodopa for enhanced symptom control.
- Effective in managing extrapyramidal disorders caused by antipsychotic/centrally acting drugs such as phenothiazines, thioxanthenes, dibenzoxazepines, and butyrophenones.
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ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Tricalm acts primarily as a muscarinic acetylcholine receptor antagonist (anticholinergic).
- Central effect: Higher affinity for M1 receptors in the brain → improves dopamine transmission in the striatum.
- Peripheral effect: Inhibits parasympathetic activity and relaxes smooth muscles.
May indirectly enhance dopamine release, reducing tremors, rigidity, and motor dysfunctions in Parkinson’s disease.
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✔️ Side Effects
- Dry mouth, blurred vision, dizziness, nausea, nervousness
- Constipation, urinary retention, drowsiness
- Tachycardia, pupil dilation, confusion, memory impairment
- Hallucinations, paranoia, psychosis
- Suppurative parotitis, paralytic ileus, skin rashes
- Exacerbation of glaucoma (can lead to blindness)
- Neuroleptic Malignant Syndrome (on abrupt withdrawal)
✔️ Dosage & Administration
Individualized dosing – start low and increase gradually, especially in elderly patients.
Idiopathic Parkinsonism: Usually 6–10 mg/day (may go up to 12–15 mg in some cases).
Drug-induced Parkinsonism: 5–15 mg/day (starting from 1 mg; adjust as needed).
With Levodopa: Typically 3–6 mg/day in divided doses; both drugs may need dose reduction.
Best tolerated when divided into 3 doses with meals (higher doses may be split into 4).
Avoid abrupt withdrawal – may trigger worsening Parkinsonism or Neuroleptic Malignant Syndrome (NMS).
Not established for use in children.
✔️ Contraindications
Hypersensitivity to trihexyphenidyl.
Narrow-angle glaucoma (risk of blindness).
✔️ Drug Interactions
Additive CNS depression: Alcohol, barbiturates, opioids, cannabinoids.
Enhanced anticholinergic effect: Tricyclic antidepressants, MAO inhibitors.
Concomitant use with neuroleptics ↑ risk of tardive dyskinesia.
With levodopa → may require dose adjustment due to increased involuntary movements.
✔️ Pregnancy & Lactation
Limited safety data in pregnancy; use only if benefit outweighs risk.
May suppress lactation; caution if used in breastfeeding mothers.
✔️ Precautions & Warnings
- Monitor intraocular pressure before and during therapy (risk of angle-closure glaucoma).
- Use cautiously in hot climates or patients with impaired sweating → risk of severe hyperthermia.
- Caution in the elderly, alcoholics, and patients with CNS disease.
- May cause anhidrosis (absence of sweating) → reduce dose if symptoms occur.
- Avoid abrupt discontinuation to prevent NMS.
✔️ Storage:
Store below 30°C, in a dry place, protected from light.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
